Veteran running back Cordarrelle Patterson is listed as doubtful and rookie center Zach Frazier has been ruled out — both with ankle injuries — for the Pittsburgh Steelers’ home game Mondy night against the New York Giants.

The Steelers (5-2) also will be without outside linebacker Nick Herbig and rookie wide receiver Roman Wilson because of hamstring issues. Linebacker Tyler Matakevich (hamstring) and offensive tackle Dylan Cook (foot) each are in the 21-day window to return from injured reserve and are out against the Giants (2-5).

Patterson, 33, was a limited practice participant on Thursday, Friday and Saturday. He has not played since Sept. 29 in a 27-24 loss at the Indianapolis Colts. A running back and wide receiver, he has one start in four games and has 16 carries for 92 yards and five receptions for 34 yards.

A four-time Pro Bowl selection and four-time All-Pro first-team honoree as a kick returner, Patterson is in his first season with Pittsburgh after playing for the Minnesota Vikings (2013-16), Oakland Raiders (2017), New England Patriots (2018), Chicago Bears (2019-20) and Atlanta Falcons (2021-23).

Frazier, 23, a 2024 NFL second-round selection out of West Virginia, has started six games and played 95 percent of the offensive snaps (378). He missed last Sunday’s game against the New York Jets.

Herbig, 22, will miss his third straight game. He has played in five games (two starts) this season and has eight tackles and 2.5 sacks. He is in his second season with the Steelers.

Wilson, 23, a third-round pick in the 2024 draft out of Michigan, has played in one game this season.